ea0015p142 | Diabetes, metabolism and cardiovascular | SFEBES2008
Zhang Lei
, Webber Jason
, Steadman Robert
, Ludgate Marian
Thyrotropin receptor (TSHR, signals via CREB) expression increases during adipogenesis, a process occurring in Graves orbits. CREB activation has been reported necessary and sufficient to induce adipogenesis. However, we previously demonstrated that expression of constitutively active TSHR in orbital preadipocytes stimulated early but inhibited later differentiation stages, even when PPARγ agonist induced. Overproduction of proteoglycans is also a featur...